Appearance: white crystalline powder
Specific rotation[a]D20: -25±1° (c=1% DMF)
Melting point: 153-155℃
Fmoc-Leu-OH; Fmoc-L-leucine 35661-60-0 is described to act as a chemically distinct ligand and modulator of PPARγ (peroxisome proliferator-activated receptor γ). Fmoc-L-leucine is demonstrated to increase intracellular Ca2+ and to mobilize Ca2+ stores in human bladder female transitional cancer cells.
Fmoc-Leu-OH is isomeric with Fmoc-Ile-OH. Like isoleucine, leucine has branching in the sidechain. The branching is at the gamma carbon instead of the beta carbon as in isoleucine.
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