Appearance: white to off-white powder
Specific Rotation [20/D]: -28.5±2.5° (c=1 in DMF)
Melting Point: 153~156℃
Moisture: 1.0% max
Fmoc-Tyr(tBu)-OH; Fmoc-O-tert-butyl-L-tyrosine 71989-38-3 is the preferred tyrosine derivative for solid phase peptide synthesis by Fmoc protocols. Protecting the Tyr sidechain may not be essential in the synthesis of small peptides. If the phenolic functional group of tyrosine does become acylated during a coupling reaction, the subsequent treatment with piperdine to remove Fmoc-groups will also remove any acylation of the phenolic function. Using Fmoc-Tyr(tBu)-OH in peptide synthesis is more efficient, however, since none of the activated amino acids are used unproductively in acylating exposed tyrosine side-chains. The use of Fmoc-Tyr(tBu)-OH also eliminates all potential for side products arising from the acylation of the tyrosine side-chain.
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